mRNA-DC Vaccines
Dendritic cells (DCs) are the most potent antigen-presenting cells (APCs), capable of processing and presenting antigens via major histocompatibility complex (MHC) class I and II molecules to both the innate and adaptive immune systems. DCs play a central role in initiating and regulating immune responses. Consequently, they have been extensively investigated as a means to stimulate cancer-specific T-cell responses.
mRNA is an attractive vector for delivering tumor antigens to dendritic cells (DCs). DCs can internalize mRN CD8+ A-encoded antigens via electroporation, introducing the mRNA into the cytoplasm, where it is translated into protein. The protein is then processed into peptides and presented on the cell surface toT cells.
